FDA safety concern

Selank acetate

Also known as Selank, TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro

LAST VERIFIEDAug 12, 2026Against linked primary sources
PL
WHAT THIS MEANS NOWFDA safety concern
FDA REVIEW STATUSFDA safety concern
HUMAN STUDIESSmall active-comparator trial
WHAT COMES NEXTFurther FDA evaluation
01FDA scientific review
02Meeting announced
03Committee vote
04Final FDA decision
FDA approved?No
FDA-approved indicationNone
Compounding-list statusNot on the final 503A Bulks List; nomination withdrawn
Advisory-committee statusNo 503A PCAC recommendation identified
Final FDA decisionNo final 503A action or FDA approval identified
WHY IT GETS ATTENTION

Selank attracts attention as a calming or cognition-adjacent peptide, especially in anxiety and nootropic communities.

Reality check

The main clinical signal comes from a small active-comparator study, while FDA says important human safety information is lacking for the compounded-drug context.

AT A GLANCE

What a visitor should know.

PUBLIC INTERESTRisingHow much attention this peptide is receiving
HUMAN STUDIESLimited human evidenceAnimal and laboratory results are kept separate
EVIDENCE GAPWideHow far public interest has moved beyond human evidence
NEW EVIDENCEMonitoringNo post-briefing change in human-evidence classification has been verified in Peplyst's monitored source set.
Technical details: aliases, tracked claims, and data record
MOST RECENT FDA UPDATE

FDA's current safety page lists the withdrawn Selank acetate nomination

FDA says compounded Selank acetate may pose immunogenicity and product-quality risks and that important human safety information is lacking.

What this tells us

The public FDA record contains an unresolved safety concern.

What it does not tell us

This is not a committee vote, final 503A rule, or FDA approval decision.

WHAT COMES NEXTFurther FDA evaluation

FDA has not posted a 503A committee recommendation or final-list action for Selank acetate in the tracked source record.

Read the FDA source
REGULATORY HISTORY

How the FDA record developed.

This timeline separates early nominations and scientific reviews from committee votes and final FDA decisions.

Verified August 12, 2026
FDA safety record

FDA's current safety page lists the withdrawn Selank acetate nomination

FDA says compounded Selank acetate may pose immunogenicity and product-quality risks and that important human safety information is lacking.

Read the source ↗
April 1, 2020
Firm-specific warning letter

FDA cited one compounder's Selank products

FDA said the firm's Selank products did not qualify for the claimed 503A exemptions under the circumstances described in the letter.

Read the source ↗
STUDIES AND EVIDENCE

What has actually been studied?

Human studies appear on the left. Animal, cell, and laboratory studies appear on the right because they cannot establish that a treatment works in people.

H
Human evidenceStudies or observations involving people
Small randomized active-comparator clinical study (2008)

A Russian-language study compared Selank in 30 patients with medazepam in 32 patients and reported similar anxiolytic effects. The small sample, active comparator, and limited methodological visibility leave benefit uncertain.

Read the study on PubMed
P
Preclinical evidenceAnimal, cell, or laboratory research
Laboratory and animal literature reviewed by FDA

Mechanistic and animal findings do not resolve the lack of adequate human effectiveness and safety information for compounded Selank acetate.

Read the FDA review
SAFETY & UNCERTAINTY

Important unknowns.

  • FDA identifies possible immunogenicity, aggregation, impurity, and active-ingredient characterization concerns.
  • FDA says it lacks important human safety information for the proposed compounded-drug context.
  • The small published clinical study used an active comparator rather than placebo and does not establish broad effectiveness or long-term safety.

These are evidence and regulatory uncertainties, not an individualized assessment of whether a treatment is appropriate.

SOURCE DOCUMENTS

Read the original sources.